Protein name:
Kit ligand ;
Alternative:
Stem cell factor (SCF) ;Mast cell growth factor (MGF) ;c-Kit ligand ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.
Function:
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Subcellular Location:
Soluble KIT ligand
Secreted
Protein Attributes:
50:
MKKTQTWIIT | CIYLQLLLFN | PLVRTQGICR | NRVTDDVKDV | TKLVANLPKD |
100:
YKITLKYVPG | MDVLPSHCWI | SEMVEQLSVS | LTDLLDKFSN | ISEGLSNYSI |
150:
IDKLVKIVDD | LVECMEEHSF | ENVKKSSKSP | EPRLFTPEKF | FGIFNRSIDA |
200:
FKDLEMVAPK | TSECVISSTL | TPEKDSRVSV | TKPFMLPPVA | ASSLRNDSSS |
250:
SNRKASDSIE | DSSLQWAAVA | LPAFFSLVIG | FAFGALYWKK | KQPNLTRTVE |
274:
NIQINEEDNE | ISMLQEKERE | FQEV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
Chicken
Dog
Pig
ELISA Kit for Pig Kit ligand
ELISA Kit for Pig Kit ligand
ELISA Kit for Pig Kit ligand
ELISA Kit for Pig Kit ligand
ELISA Kit for Pig Kit ligand
ELISA Kit for Pig Kit ligand
ELISA Kit for Pig Kit ligand
CLIA Kit for Pig Kit ligand
CLIA Kit for Pig Kit ligand
CLIA Kit for Pig Kit ligand
CLIA Kit for Pig Kit ligand
CLIA Kit for Pig Kit ligand
CLIA Kit for Pig Kit ligand
CLIA Kit for Pig Kit ligand
Polyclonal Antibody for Pig Kit ligand
Polyclonal Antibody for Pig Kit ligand
Polyclonal Antibody for Pig Kit ligand
Polyclonal Antibody for Pig Kit ligand
Polyclonal Antibody for Pig Kit ligand
Polyclonal Antibody for Pig Kit ligand
Polyclonal Antibody for Pig Kit ligand
Monoclonal Antibody for Pig Kit ligand
Monoclonal Antibody for Pig Kit ligand
Monoclonal Antibody for Pig Kit ligand
Monoclonal Antibody for Pig Kit ligand
Monoclonal Antibody for Pig Kit ligand
Monoclonal Antibody for Pig Kit ligand
Monoclonal Antibody for Pig Kit ligand
Protein for Pig Kit ligand
Protein for Pig Kit ligand
Protein for Pig Kit ligand
Protein for Pig Kit ligand
Protein for Pig Kit ligand
Protein for Pig Kit ligand
Protein for Pig Kit ligand
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Uterus .
2.
"Sequencing, mapping and nucleotide variation of porcine coat color genes EDNRB, MYO5A, KITLG, SLC45A2, RAB27A, SILV and MITF."
Okumura N.
,
Hayashi T.
,
Sekikawa H.
,
Matsumoto T.
,
Mikawa A.
,
Hamasima N.
,
Awata T.
Anim. Genet.37:80-82(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ARG-124; ASN-149 AND ALA-248
tissue :
Kidney .